Author: Abergel, R.J.
Paper Title Page
THPMP051 Development of 211-Astatine Production in the Crocker Nuclear Laboratory Cyclotron 3564
  • E. Prebys
    Fermilab, Batavia, Illinois, USA
  • R.J. Abergel
    UCB, Berkeley, California, USA
  • W.H. Casey
    University of California at Davis (UC Davis), Davis, California, USA
  • D.A. Cebra
    UCD, Davis, California, USA
  There is a great deal of interest in the medical community in the use of the alpha-emitter 211-At as a therapeutic isotope. Among other things, its 7.2 hour half life is long enough to allow for recovery and labeling, but short enough to avoid long term activity in patients. Unfortunately, the only practical technique for its production is to bombard a 209-Bi target with a ~29 MeV alpha beam, so it is not accessible to commercial isotope production facilities, which all use fixed energy proton beams. The US Department of Energy is therefore supporting the development of a "University Isotope Network" (UIN) to satisfy this need. Our prposoal is to retrofit the variable-energy, multi-species cyclotron at the Crocker Nuclear Laboratory at the University of California Davis with an internal Bi-209 target, such that we can put at least 100 uA of 29 MeV alpha particles on target without concerns about extraction efficiency. Using very conservative assumptions, we are confident we will be able to produce 60 mCi of 211-At in solution in an eight hour shift, which includes setup, exposure, and chemical recovery. This poster will cover the design of the target, as well as the required chemical processing and reliability upgrades.  
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About • paper received ※ 15 May 2019       paper accepted ※ 22 May 2019       issue date ※ 21 June 2019  
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